For instance, through the formation of neutrophil extracellular traps (NETs), neutrophils induce an inflammatory response in epithelial cells via Toll-like receptor 4 (TLR4)-dependent pathways, leading to the upregulation of pro-inflammatory cytokines such as IL-1β, IL-6, IL-8, and IL-1; this creates a tumor-promoting environment [24]. This evidence concerns the gene IL1B and neoplasm.