Obesity is associated with chronic low-grade inflammation, which can promote carcinogenesis as excess adipose tissue leads to the secretion of inflammation-related macrophages and adipokines such as interleukin (IL)-6, plasminogen activator inhibitor-1 (PAI-1), and C-reactive protein (CRP). This evidence concerns the gene SERPINE1 and obesity due to melanocortin 4 receptor deficiency.