NOTCH3 and Wilson disease: Lastly, the FC of WD pigs had a downregulation of calcium-ion-bonding-related gene levels (Figure 2C), which are involved in intercellular signaling and cell-fate determination and include Notch Receptors 3 and 4 (NOTCH 3, NOTCH 4), Delta Like Canonical Notch Ligand 4 (DLL4), EGF Like Domain Multiple 8 (EGFL8), and Nidogen 1 (NID1).