Furthermore, the FC of WD animals displayed a downregulation of genes associated with the cytoskeleton and ECM organization (Figure 2A), such as Phosphatase and Actin Regulator 2 (PHACTR2), Peroxidasin (PXDN), Collagen Type XVIII Alpha 1 Chain (COL18A1), Supervillin (SVIL), EH Domain Containing 2 (EHD2), Filamin C (FLNC), EH Domain Binding Protein 1 Like 1 (EHBP1L1), FYVE (gene named after the first four proteins it was found in: Fab1p, YOTB, Vac1p, and EEA1), Rho Guanine Nucleotide Exchange Factor (RhoGEF), and PH Domain Containing 2 and 3 (FGD2, FGD3). This evidence concerns the gene ARHGEF28 and Wilson disease.