CYCS and Wilson disease: Mitochondria are also involved in the initiation of apoptosis [62]; CYCS gene encoding cytochrome c was upregulated in the FC of WD pigs, and this increase was previously associated with elevated rates of cell death [62], while BCL2 protein, which prevents cytochrome c release [63], has been found reduced in WD-fed pigs and in the transcriptomes of patients consuming a high fat, ketogenic diet [64].