Decreased level of DCHS1, as found in the FC of WD-fed pigs, has been shown to negatively impact the differentiation of neural stem cells [72], while an upregulation of DCHS2 expression, as detected in the FC of WD-fed pigs, has been associated with increased levels of amyloid-beta, a key hallmark of AD [73]. The gene discussed is DCHS1; the disease is Alzheimer disease.