As for assessed laboratory parameters at admission in the ED, only LDH (Sepsis-3: median 325 vs. 227 mg/dL, p < 0.001) and serum albumin (Sepsis-2: median 26 vs. 30 g/L, p ≤ 0.05) levels show significant differences between 30-day mortality and 30-day survival groups, and seemed to be useful in the early diagnosis of sepsis regarding clinical outcomes. This evidence concerns the gene ALB and Sepsis.