HE4 was a significant positive predictor of both MI (HR 1.403, 95% CIL 1.186–1.66, p <0.001) and MACEs (HR 1.353, 95% CI: 1.147–1.596, p < 0.001), even after adjusting for age, sex, hypertension, hypercholesterolemia, diabetes mellitus, smoking status, congestive heart failure, and coronary artery disease. The gene discussed is WFDC2; the disease is familial hypercholesterolemia.