IL6 and obesity due to melanocortin 4 receptor deficiency: In the general population, obesity is linked to elevated oxidative stress and inflammation via the release of pro-inflammatory adipokines (such as leptin, visfatin, and resistin), anti-inflammatory adipokines (such as adiponectin and apelin), chemotactic factors (such as MCP-1), and pro-inflammatory cytokines (such as TNF-α, IL-1β, and IL-6) [14,15].