APC and colorectal carcinoma: A mixture of Lactobacillus species (namely two strains of L. plantarum and one strain each of L. reuteri, L. brevis, and L. rhamnosus) was found to inhibit the in vitro proliferation of human CRC cell lines and the in vivo growth of CRC in mice through modulation of the expression of APC (which was increased) and of β-Catenin (which was decreased) [158].