ATG5 and neoplasm: In several in vitro and in vivo CRC settings, the miRNA-mediated knock-down of autophagy was associated with increased resistance to therapy, tumor growth, invasiveness, metastasization, and poor prognosis, such as was the case with MiR-338-5p silencing of PI3KC3 [74] and miR-183-5p silencing of ATG5 [75].