In a rat model of intervertebral disc degeneration, UA suppresses TNF-α-mediated MMP-3/13 expression and alleviates oxidative stress-induced nucleus pulposus stem cell senescence via the SIRT1/peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) pathway [87,88]. The gene discussed is PPARGC1A; the disease is Intervertebral disk degeneration.