In amyloid precursor protein (APP)/presenilin 1 (PS1) transgenic AD mice, UA enhances brain adenosine 5′-monophosphate-activated protein kinase (AMPK) activation, attenuating NF-κB and MAPK activity, mitigating neuroinflammation, and supporting synaptic recovery [61]. The gene discussed is NFKB1; the disease is Alzheimer disease.