CDK5 and Parkinson disease: Furthermore, studies on the cyclin-dependent kinase 5 (CDK5)—ubiquitin-specific peptidase 30 (USP30) signaling pathway revealed that UA restores mitophagy efficiency, counteracting MPTP-induced activation of the mitochondrial antiviral signaling protein (MAVS) inflammatory pathway and offering a specific therapeutic target for toxin-induced PD [121].