TLR9 and inflammatory bowel disease: The effect of EBV in a mouse model of IBD and the effect of TLR9 inhibition on EBV-exacerbated colitis was evaluated based on trends in the DAI, macroscopic assessments of the colon, histological damage scoring of the H&E-stained colon cross sections, and immunofluorescence staining of pro-inflammatory markers in colon tissue.