The release of these pro-inflammatory cytokines, such as interleukin (IL)-6, interleukin-1β (IL-1β), and tumor necrosis factor alpha (TNF-α), leads to the perpetuation of an inflammatory response, resulting in increased activation of signaling pathways that are associated with the hallmarks of cancer, including survivability, proliferation, reactive oxygen species (ROS) production, and invasion into other tissues [7,12]. The gene discussed is TNF; the disease is cancer.