TMEM43 and cardiomyopathy: Moreover, it was also found that overexpression of wild-type and p.P111L-mutant TMEM43 in a transgenic zebrafish model was associated with cardiac enlargement and cardiomyocyte hypertrophy, which confirms the role of transcriptomic alterations in the pathogenesis of TMEM43-associated cardiomyopathy [111].