A strong correlation was presented between the production of IL-6 with IL-8 and TNF-α; the relationship between these cytokines has been reported in other diseases such as breast cancer, where the levels of IL-6, IL-8 and TNF-α were correlated with the clinical disease stage and lymph node metastasis [76]. The gene discussed is IL6; the disease is metastatic malignant neoplasm in the lymph nodes.