We identified a particular pro-inflammatory profile in patients with NB, finding significantly elevated serum levels of IL-8, IL-6, IL-12, TNF-α and IFN-γ compared to healthy controls; this suggests their involvement in the development of this tumor and the possibility that a differentially expressed serum cytokine profile may be useful to detect the presence of NB, allowing early diagnoses. This evidence concerns the gene TNF and neuroblastoma.