Precise quantification of raft-associated components—such as caveolin-1, IGF-1R, BDNF, GPI-anchored proteins, and their by-products—in CSF or blood, combined with multivariate methods like discriminant function analysis, could serve as a valuable diagnostic tool for more accurate detection and monitoring of Alzheimer’s disease [85]. Here, BDNF is linked to early-onset autosomal dominant Alzheimer disease.