NOS3 and endothelial dysfunction: The interplay between blood pressure and cholesterol is mediated by oxidative stress (contributing to endothelial dysfunction and hypertension), cytokines and neuropeptides like angiotensin II, through mechanisms involving bone marrow and microglia activation and genetic factors (such as the endothelial nitric oxide synthase gene variant), all contributing to cardiovascular disease risk [32,33,34,35].