It is worth mentioning that lipids play a significant role in the regulation of arterial blood pressure through several mechanisms involving free fatty acids (can lead to endothelial dysfunction, vascular hypertrophy, and vessel wall stiffness), atrial natriuretic peptide (promotes lipolysis and increases free fatty acid availability), short-chain fatty acids from gut microbial fermentation (interact with specific receptors in blood vessels), and polyunsaturated fatty acids (reducing oxidative stress and regulating vasodilator release) [36,37,38,39]. The gene discussed is NPPA; the disease is endothelial dysfunction.