Furthermore, the aggregation of choroid plexus (ChP) macrophages can amplify NF-κB signaling in epithelial cells through the tumor necrosis factor alpha/tumor necrosis factor receptor 1 (TNF-α/TNFR1) pathway, promoting excessive cerebrospinal fluid (CSF) secretion and worsening hydrocephalus. The gene discussed is NFKB1; the disease is Hydrocephalus.