It is now unanimously accepted in the literature that the origin of schwannomas is associated with a mutation in a cytoskeletal protein called Merlin, Neurofibromin 2, or schwannomin [15], which belongs to the ERM (Ezrin–Radixin–Moesin) protein family [8,13,15,21] and is regulated by the tumor suppressor gene NF2. The gene discussed is MSN; the disease is schwannoma.