Since miRNA-150 targets the translation initiation factor 4E (eIF4E)—a key component of the AKT signaling pathway—MALAT1 indirectly activates AKT signaling by sponging miRNA-150, thereby promoting airway smooth muscle cell proliferation and migration, which contributes to airway remodeling in asthma [50]. The gene discussed is AKT1; the disease is asthma.