IL4 and asthma: Eosinophils contribute to asthma pathophysiology by releasing cationic proteins (MBPs, EPOs, ECPs, and EDNs), chemokines (RANTES and eotaxin-1), pro-inflammatory cytokines (IL-2, IL-4, IL-5, IL-10, IL-12, IL-13, IL-16, IL-18, and transforming growth factor (TGF)-α/β), and lipid mediators (LTC4, platelet-activating factor, thromboxane B2, and prostaglandins) [96,97].