In comparison, the commercial nuclear matrix protein-22 (NMP22 BladderChek®) [10], bladder tumor antigen (BTA-Stat® and BTA-Trak®) [11], and mini chromosome maintenance-5 (MCM5) protein (ADxBladder®) [26] single-plex assays have lower respective sensitivities of 25%, 36%, and 50% for detecting low-grade BC. The gene discussed is NUMA1; the disease is breast cancer.