Experimental autoimmune encephalomyelitis mice models show early AQP4 depolarization and a 40–50% fall in glymphatic inflow [31], and patients with MS show reduced glymphatic function—as measured by diffusion along perivascular spaces (DTI-ALPS) [32,33,34,35]—and other proxies of glymphatic dysfunction such as enlarged perivascular spaces [36]. This evidence concerns the gene AQP4 and myeloid sarcoma.