In Parkinson’s disease, downregulation of protective miRNAs (miR-7, miR-124, miR-195, miR-29a/c, miR-218-5p, miR-221-3p, and miR-101a-3p) allows for uncontrolled accumulation of α-synuclein and LRRK2, thereby activating the NF-κB and NLRP3 inflammasome signaling pathways, which are further enhanced by the upregulation of miR-155-5p, miR-135b, and miR-20a-5p via the suppression of SOCS1. The gene discussed is SNCA; the disease is Parkinson disease.