TARDBP and nevus comedonicus syndrome: Similarly, limbic-predominant TDP-43 encephalopathy (LATE), which represents the clinical manifestation of limbic-predominant TDP-43 encephalopathy-neuropathologic changes (LATE-NC) and is often associated with PART [99], is characterized by the presence of TDP-43 and can lead to more global cognitive involvement, particularly affecting semantic memory, especially when comorbid with hippocampal sclerosis [16].