MAPT and supranuclear palsy, progressive, 1: Although FDG-PET can sometimes reveal patterns suggestive of mixed pathologies, for example, showing features consistent with both PSP and AD [138], it is not specific enough to directly identify TDP-43 pathology or its co-occurrence with tau, even though the presence of both pathologies could potentially lead to more widespread metabolic dysfunction and more hypometabolism signals [137,138,148].