ACHE and hypothyroidism: This natural compound decreased AChE activity in the cerebral cortex and hippocampus of STZ-diabetic rats [23], in cerebral cortex synaptosomes of rats exposed to cadmium [70], and in cerebral cortex synaptosomes of rats with hypothyroidism induced by methimazole (MMI) [71], and increased acetylcholine (Ach) levels in the brain of stressed mice [60].