SERPING1 and angioedema: The most common HAE types (with an estimated global prevalence of approximately 1 in 50,000–100,000) are caused by C1 inhibitor (C1INH) deficiency, i.e., HAE-C1INH-Type1, or dysfunction, i.e., HAE-C1INH-Type2, leading to uncontrolled bradykinin production, vascular permeability, and subsequent angioedema [1–5].