Under short-term Oxa treatment, both AGC1-KD and Oxa-resistant CRC cells still exhibited a stronger antioxidant stress capacity, as evidenced by a higher GSH/GSSG ratio (Fig. 6I), a lower NAD+/NADH ratio (Fig. 6J), a less ROS accumulation (Fig. 6K), and stronger anti-apoptosis capacity (Fig. 6I), suggesting that AGC1-KD cells and Oxa-resistant cells exhibit enhanced antioxidant capacity. This evidence concerns the gene SLC25A12 and colorectal carcinoma.