We classified the RNA-seq dataset described earlier (Supplementary Figs. S1A and S1B) based on EZH2 expression levels (EZH2low and EZH2high), and found that t(4;11) pro-B-ALL patients classified as EZH2high tended to cluster separately from germline KMT2A patients [OR = 0.291, 95% CI (0.045–1.898), p = 0.197] (Supplementary Fig. S2F), suggesting that high levels of EZH2 shift the transcriptional profile of infants with t(4;11) pro-B-ALL away from germline KMT2A individuals, oppositely to the effect caused by an elevated HDAC7 expression. This evidence concerns the gene EZH2 and acute lymphoblastic leukemia.