Despite both groups display significantly lower HDAC7 levels than infants lacking KMT2A alterations [26], HDAC7high t(4;11) leukemia cases grouped significantly with germline KMT2A as compared with HDAC7low patients [OR = 10.286, 95% CI (1.018–103.953), p < 0.05] (Supplementary Fig. S1B). This evidence concerns the gene KMT2A and leukemia.