HDAC7 and acute lymphoblastic leukemia: Importantly, analysis of BM cells extracted at the experimental endpoint revealed that MI-538 + chidamide treatment induced HDAC7 expression in PDX cells (Fig. 7H and Supplementary Fig. S8C), supporting our initial hypothesis that the precise upregulation of HDAC7 reduces the malignant capacity and treatment unresponsiveness of t(4;11) pro-B-ALL.