As previously illustrated, autophagy is a critical process in melanoma, involving autophagosome formation and its subsequent fusion with lysosomes for cargo degradation; from a molecular point of view, its regulation is based on mTOR-dependent and independent pathways, such as adenosine monophosphate-activated protein kinase (AMPK), MAPK, ER, and oxidative stress [90, 146]. This evidence concerns the gene MTOR and melanoma.