Moreover, the CDK1 inhibitor CurE induces ZBP1-dependent PANoptosis and suppresses the proliferation of adrenocortical carcinoma cells, and adenosine deaminase acting on RNA 1 (ADAR1) depletion exerts similar effects under the treatment of NEIs plus IFN-γ in colorectal cancer and melanoma models [92, 103]. The gene discussed is ZBP1; the disease is adrenal cortex carcinoma.