Depletion of ZBP1 markedly decrease PANoptotic cell death in adrenocortical carcinoma, breast cancer and head and neck squamous cell carcinoma cells, and results in a significant tumorigenesis in colorectal cancer, melanoma and hemophagocytic lymphohistiocytosis mice models [85, 92, 93, 103]. The gene discussed is ZBP1; the disease is adrenal cortex carcinoma.