CD274 and lung carcinoma: Moreover, elevated serum levels of PRO-C3 have been associated with poor prognosis in patients with metastatic melanoma treated with either anti-CTLA-4 [138] or anti-PD-1 [139] therapies, while high collagen levels in lung cancer correlate with suboptimal responses to anti-PD-1/PD-L1 treatment [24].