The tumor cells expressing MAGEs likely comprise undifferentiated progenitor-like cells with high MYC activity (subpopulation program B), as Hovestadt et al. [21] reported that more than 88% of the cells from the group 3 MBs, in which multiple MAGEs were expressed (Figs. 1D, 2C, and S3A), were annotated as program B. This evidence concerns the gene MYC and neoplasm.