Etiology of SHH-MBs has been attributed to genetic changes in SHH signaling, including mutations in the SHH receptor PTCH, SHH inhibitor SUFU, or SHH transducer SMO, GLI1/2 amplifications, and mutations in MYCN and TP53 [21, 28, 55]. The gene discussed is MYCN; the disease is Mobius syndrome.