The score incorporates key predictors significantly associated with infection recurrence, including age, BMI, mandibular infection, post-extraction, post-implantation and post-augmentation infection, trismus, odynophagia, non-palpable mandibular margin, cervical drainage, elevated inflammatory markers (CRP, WBC, ANC, PCT), polymicrobial infections and postoperative ICU stay. The gene discussed is CRP; the disease is infection.