oat-ELNs inhibit alcohol-induced brain inflammation by blocking inflammatory cytokines (IL-6, IL-1β, TNF-α) through the Dectin-1/HPCA/Rab11a pathway. oat-ELNs prevented activation of the NF-κB signaling pathway and reduced neuronal apoptosis in the hippocampus, improving memory in alcohol-treated mice. The gene discussed is RAB11A; the disease is brain inflammatory disease.