This is exemplified by one of the most up-regulated transcripts, i.e., VCAM1, a STAT3-target involved in leukocyte-endothelial cell adhesion and signal transduction, which may also play a role in the development of rheumatoid arthritis [38], an autoimmune disorder often reported in association with T-LGLL. The gene discussed is STAT3; the disease is rheumatoid arthritis.