Variant calling from RNA-seq data revealed a subclonal STAT5B variant in one STAT5B-mutated case, as well as oncogenic variants in seven additional genes across different patients, all previously reported in T-LGLL, obtaining a better characterization of the patient genetic profile (Supplementary Methods and Supplementary Table 2). This evidence concerns the gene STAT5B and T-cell large granular lymphocyte leukemia.