Previous studies have demonstrated that peripheral blood monocytes can serve as biomarkers for various diseases, such as fibrotic diseases,52 multiple myeloma,53 and autoimmune encephalitis.54 In our studies, the change in the proportion of MX1+ monocytes was consistent with the change in the Child‒Pugh score—patients who showed a greater decrease in score after treatment maintained a lower level of MX1+ monocytes. Here, MX1 is linked to plasma cell myeloma.