Our findings revealed a significantly higher expression of B7-H3 in CRC tumors compared to normal tissue, and a favorable killing effect of B7-H3-redirected CAR-T cells against metastatic CRC in vitro and in vivo without obvious toxicity, highlighting the potential of B7-H3-redirected CAR-T cells as a promising therapeutic strategy for metastatic CRC. Here, CD276 is linked to colorectal carcinoma.