In addition to PIEZO1 gene variant associations with cardiac valve abnormality (Faucherre et al. 2020) and pericardial effusion (Ludlow et al. 2023), recapitulation of a human PIEZO1 gain-of-function variant in mice caused mild cardiac hypertrophy and fibrosis (Bartoli et al. 2022b), and there is a case report that associated a potential gain-of-function PIEZO1 variant with cardiomyopathy (Cui et al. 2021). The gene discussed is PIEZO1; the disease is pericardial effusion.