Among the proteins in this family, the beta-1 adrenergic receptor(ADRB1) plays a central role in regulating cardiovascular functionand is a key therapeutic target in the treatment of heart diseases., Drugs such as metoprolol, bisoprolol, and atenolol act as ADRB1antagonists (i.e., β-blockers) and are widely prescribed forhypertension, heart failure, and arrhythmias, making this receptorcritical for managing cardiovascular health and preventing life-threateningevents like myocardial infarction and stroke. This evidence concerns the gene ADRB1 and heart failure.