Despite its high mortalityrate, melanoma is highly curable if diagnosed and treated early. EV biomarkers for melanoma include proteinssuch as MCSP, MCAM, LNGFR, and ErbB3, which show great potential forimproving early diagnosis and prognosis. In addition, EV miRNA profiling has identified miR-1180–3pas a promising diagnostic marker for melanoma. This evidence concerns the gene MCAM and melanoma.