EWSR1 and cancer: Ewing sarcoma (EWS) is a rare cancer that startsin the bones ofkids and teenagers and is characterized by chromosomal translocationbetween the EWS gene (chromosome 22) and membersof the ETS family of transcription factors (such as FLI1, ERG, ETV1,E1AF, etc.)resulting in fusion oncoprotein/transcription factor thatdrive tumor development. The clinicalpresentation of EWS is quite often nonspecific, with the most commonsymptoms at presentation consisting of pain, swelling, or generaldiscomfort.