The pointestimate of the AUC to distinguish pancreatic cancer (n = 106) from healthy controls (n = 106) was higherfor apoA2-ATQ/AT (0.879; 95% confidence interval [CI], 0.832–0.925)than for CA19–9 (0.849; 95% CI, 0.793–0.905), meetingthe primary end point of the study. EVproteins can also be analyzed in combination with EV RNAs for diagnosis.A recent study analyzed 3 protein markers (GPC1, CD63, and HER2) and3 RNA markers (snRNA U6, GPC1 mRNA, and miR-10b) in EVs from 30 humanplasma samples. This evidence concerns the gene GPC1 and familial pancreatic carcinoma.