Finally, EV-associated lncRNAssuch as HOTAIR and MALAT1 may serveas biomarkers for the diagnosis and prediction of colorectal cancer. SNHG3 may be another option, as this EV-derivedlncRNA was found to promote metastasis in colorectal cancer by enhancingthe RNA stability of β-catenin through HNRNPC-mediated mechanisms. The gene discussed is MALAT1; the disease is colorectal cancer.