A high-throughput integrated magneto-electrochemical (HiMEX)device was developed for this purpose, featuring a 96-well assay thatenriches EVs with antibody-coated magnetic beads and also performselectrochemical detection (Figure A). This system utilizesa combination of antibodies targeting clinically relevant tumor biomarkers(EGFR, EpCAM, CD24, and GPA33) for the detection and analysis of colorectalcancer. Here, EPCAM is linked to neoplasm.