CD53 can indicate illnesses that impact the function of immunecells, such as specific leukemias and lymphomas, offering informationon the immune health of individuals. CD54 (ICAM-1) helps attach EVs to target cells by binding with integrins.It is connected to immune reactions and could be involved in transmittinginflammatory signals. As a biomarker,CD54 is useful in diagnosing and monitoring inflammatory disorders,such as rheumatoid arthritis and inflammatory bowel disease. The gene discussed is ICAM1; the disease is rheumatoid arthritis.