Several proteins derived from pancreatic cancer cells, suchas GPC1, EpCAM, Ephrin type-A receptor 2 (EphA2), MUC1, and EGFR,are frequently detected in EVs from pancreatic cancer patients andare being investigated as potential diagnostic biomarkers in clinicalstudies.,−,  In EVs isolated from patients with pancreatic ductal adenocarcinoma(PDAC), the expression levels of GPC1 and EpCAM, as well as ITGαvand ITGβ5, show a strong correlation with the disease. This evidence concerns the gene ITGB5 and pancreatic neoplasm.