Among these, miR-21, miR-23a, and miR-1246have shown particularly high diagnostic accuracy, with AUC valuesapproaching 1, and EV-miR-1246, enhanced by a dominant P53 mutation in colorectal cancer, contributes to ECM degradation, acritical factor in cancer malignancy., In additionto miR-21, miR-23a, and miR-1246; miR-150–5p also shows promiseas a diagnostic and prognostic marker, with an AUC value of 0.87.Other miRNAs relevant to colorectal cancer have been identified. The gene discussed is TP53; the disease is colorectal cancer.