PIK3CA and cancer: EVs extracted from colorectal cancercells found in blood alsocontain fragments of DNA or RNA that reflect mutations in genes suchas KRAS, APC, p53, PIK3CA, and BRAF, which can potentiallyact as biomarkers for specific forms of this type of cancer.,, One form of colorectal canceris due to the KRAS G12C mutation, reported in around40–50% of cases and linked to a lack of response to anti-EGFRtreatments like cetuximab and panitumumab. Recent research demonstrated that Rab13 plays a part in the secretionof EVs from colorectal cancer cells with a mutated KRAS gene.