Microglia activated by LPS stimulation led to the production of proinflammatory cytokines and mediators, such as TNF-α, IL-6, and IL-1β, and their chronic increase predisposes the CNS to neuroinflammation, which may result in the development of neurodegenerative diseases, such as AD [25,26]. This evidence concerns the gene IL6 and neurodegenerative disease.