The higher risk may be due to males with MASLD being more likely to have concurrent alcohol use, which can exacerbate mortality risks, even with moderate consumption.45 The sex disparity in MASLD-related cirrhosis may be further explained by the higher expression of liver formyl peptide receptor 2 in female mice.46 As an estrogen-regulated modulator of inflammatory responses, formyl peptide receptor 2 confers greater protection against MASLD progression in females. The gene discussed is FPR2; the disease is metabolic dysfunction-associated steatotic liver disease.