In assessing potential side effects from CAR-T therapy, we studied several factors associated with CRS, such as CRP, IL-15, IL-6, TNF-α, IFN-γ, and Granzyme B. According to Fig. 7, most of these factors showed a peak around Day 10 post-infusion, apart from IL-15 and TNF-α. Here, IL15 is linked to congenital rubella syndrome.