The circumsporozoite protein (CSP), the primary outer coating essential for sporozoite development and hepatocyte invasion, has long been an attractive malaria vaccine target as it is highly immunogenic and capable of inducing a dominant neutralizing titer after infection or vaccination (Hill, 2006; Kappe et al., 2004; Nussenzweig and Nussenzweig, 1989). The gene discussed is DNAJC5; the disease is infection.