ITPR1 and breast cancer: The inositol 1,4,5-trisphosphate receptor (IP3R) Ca2+ release channel and the store-operated Ca2+ entry (SOCE) channel are ubiquitously expressed and functionally linked Ca2+ shuttling mechanisms that have been shown to play important roles in the migration of breast cancer cells (Mound et al., 2017; Yang et al., 2009).