To begin to understand the mechanisms involved in promotion of a more aggressive melanoma in the zebrafish expressing wtICER, we focus here on an exploration of wtICER specific upregulated genes that have corresponding binding affinity for CREs, confirmed via ChIP-Seq data: PRKACA which encodes PKA catalytic α-subunit and glioma-associated oncogene homolog 2 (GLI2). Here, PRKACA is linked to melanoma.