STAT3 and cancer: Given its established role in maintaining oxidative homeostasis, regulating cell proliferation, and mediating apoptosis (Tan et al., 2022), GSTP1 has been further associated with chemoresistance in multiple cancer types, including its involvement in resistance to alkylating agents in breast cancer (Yang et al., 2017) and in promoting metastasis via STAT3 upregulation in colorectal cancer (Wang et al., 2022).