TNF and polycystic ovary syndrome: To date, rapid improvements in inflammatory markers, including CRP, TNF‐α, IL‐6 and IL‐1β, have only been observed after heat therapy in clinical populations with polycystic ovary syndrome and chronic heart failure, where the participants presented with markedly higher levels of inflammation at baseline (Ely, Clayton, et al., 2019; Oyama et al., 2013).