TFRC and infection: Further investigation demonstrated that mandarin fish transferrin receptor-1 (mfTfR1) plays a critical role in SDDV-induced ferroptosis, as downregulation of mfTfR1 significantly reduces SDDV replication and consequently decreases the mortality in infected mandarin fish (22); however, the exact role of mfTfR1 involvement in infection and pathogenicity of SDDV remains unknown.