Infection of HeLa cells with viruses able to induce TRIM25 HMW species (VACV-Cop, CPXV-BR) also induced the formation of TRIM25 punctae, whereas those that could not induce TRIM25 HMW species (vP811, ECTV-Mos) did not (Fig. 6G, and H). Here, MOS is linked to infection.