In cancer, neutrophils accumulate not only in primary tumors but also in distant organs.[87] In BM, neutrophils exhibit heightened immune and inflammatory signaling, including TNFα signaling, but diminished reactive oxygen species production.[88] During the early phases of BM development, primary tumors trigger astrocyte‐mediated inflammation, recruiting neutrophils to the metastatic niche.[89] Their phenotypic plasticity and role in metastasis remain subjects of ongoing intensive research. Here, TNF is linked to cancer.