Tumor‐derived exosomes critically mediate premetastatic niche formation by triggering astrocytic secretion of inflammatory cytokines (IFN‐γ, IL‐3, IL‐5, IL‐15) that establish microenvironments, sustaining tumor survival through chronic inflammation while evading immune detection via immunosuppressive reprogramming[76] (Figure1). The gene discussed is IFNG; the disease is neoplasm.