PIK3R1 and cancer: This process is integral to the regulation of various cellular activities, including inflammation, infection, metabolic balance, and tumor development.[46] Recent findings underscore the essential role of selective autophagy, which utilizes specialized cargo receptors to target ubiquitinated substrates, in the precise modulation of cancer dynamics.[27] For example, NOD‐like receptor 6 (NLRP6) enhances the interaction between the cargo receptor optineurin and p85α, encoded by phosphoinositide‐3‐kinase regulatory subunit 1 (PIK3R1), thereby amplifying PI3K/AKT signaling to drive tumorigenesis.