HARS1 and Charcot-Marie-Tooth disease: In a recent example, with funding from the RDMM, Heinemann and colleagues generated a yeast model system for the histidyl-tRNA synthetase 1 (HARS1) disease Charcot-Marie-Tooth syndrome (CMT) by replacing yeast ortholog HTS1 with human wild-type or mutant HARS1 (Qiu et al., 2023).