However, a comparative study assessing NLRP3 (NOD-like receptor protein 3), caspase-1, IL-1β, and IL-18 mRNA and protein expression in hen and human OvCa found increased protein expression of caspase-1, IL-1β, and IL-18 in surface epithelium, tumor cells, and immune cells. This evidence concerns the gene IL18 and neoplasm.